Biofilm disruptors, rifaximin, neomycin, and prucalopride gave me the first real relief I’d ever had

I'm now 47. I had both salmonella and appendicitis at around 12 or 13 years of age, and in the intervening years, dealt with severe urgency, food sensitivities, and a mix of diarrhea and constipation - that is, multiple small episodes of diarrhea a day without ever really feeling "completion." I had the wastebasket IBS diagnosis and a lot of people telling me it was all anxiety and it was in my head, and I very much have lived an agoraphobic life because of it. I also received an MS diagnosis in 2016.

In 2021 I had a phd naturopath identify and diagnose my combination SIBO with a breath test, introduce weeks of biofilm disruptors, and then a combination of neomycin and rifaximin, two courses at first, followed by supportive prucalopride. Since 2021 I've had recurring events (though usually with more than a year between!) and a couple other courses of antibiotics, which always make me feel so incredibly improved it's like a magic wand.

But I don't want to take them all the time and risk diminishing their effect. In support between, I take fibre-4 IBS safe fibre, creatine, l-glutamine, and sometimes bifido probiotics to keep things moving. Though I would have described my lifelong burden as "diarrhea" it's slow motility and "festering" that combine with the food sensitivities/diarrhea, so arguably constipation is just as serious, and my naturopath now has me on uninterrupted prucalopride, .5mg a night, going forward.